Background information on acute HIV infection Acute HIV Infection Patient Information click here Acute HIV and Prevention click here Diagnosis and Management of Primary (Acute) HIV Infection click here Pilcher, CP et al. Acute HIV Infection click here Research Results from the Options Project Hecht, FM et al. Lessons from Primary HIV Infection click here Hecht, FM et al. Use of Laboratory tests and clinical symptoms for identification for primary HIV infection. AIDS. 2002; 16: 1119-1129. click here Hecht, FM et al. Sexual transmission of an HIV-1 variant resistant to multiple reverse-transcriptase and protease inhibitors. New England Journal of Medicine. 1998; 339: 341-3. click here Davey Rt Jr et al. Immunologic and virologic effects of subcutaneous interleukin 2 in combination with antiretroviral therapy: A randomized controlled trial. Journal of the American Medical Association. 2000; 284: 183-9. click here Grant RM, Hecht FM, Warmerdam M, Liu L, Liegler T, Petropoulos CJ, Hellmann NS, Chesney M, Busch MP, Kahn JO. Time trends in primary HIV-1 drug resistance among recently infected persons. JAMA. 2002; 288(2): 239-41. click here Gascon RL, Narvaez AB, Zhang R, Kahn JO, Hecht FM, Herndier BG, et al. Increased HLA-DR Expression on Peripheral Blood Monocytes in Subsets of Subjects With Primary HIV Infection Is Associated With Elevated CD4 T-Cell Apoptosis and CD4 T-Cell Depletion. Journal of Acquired Immune Deficiency Syndrome. 2002; 30(2)20: 146-53. click here Altfeld M, Rosenberg E, Shankarappa R, Addo M, Hecht FM, Kahn JO, Walker B. Cellular Immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. Journal of Experimental Medicine. 2001. 193: 169-80. click here Schito A, Vittinghoff E, Hecht FM, Elkins K, Kahn JO, Levy JA, Oksenberg J. Longitudinal analysis of T cell receptor gene usage by CD8+ T cells in early HIV infection in patients receiving high active antiretroviral therapy. Blood. 2001; 97: 214-220. click here Janseen RS, Satten GA, Stramer SL, Rawal BD, O'Brien TR, Weblen BJ, Hecht FM, Jack N, Cleghorn FR, Kahn JO, Chesney MA, Busch MP. New testing strategy to detect early HIV-1 infection for use in incidence estimates and for clinical and prevention purposes. JAMA. 1998; 280: 42-48. click here Stranford SA, Ong JC, Martinez-Marino B, Busch M, Hecht FM, Kahn J, Levy JA. Reduction in CD8+ cell noncytotoxic anti-HIV activity in individuals receiving highly active antiretroviral therapy during primary infection. Proc Natl Acad Sci USA. 2001;98(2):597-602. click here Poster presentation of, "Sexual behavior and beliefs in recently infected MSM" click here Poster presentation of, "Relationship between seminal and plasma viral RNA among persons with primary HIV infection." click here Poster "Interleukin-2 added to HAART in primary HIV infection enhances anti-HIV immune responses" click here Poster "Is HAART for Primary/Early HIV Infection Associated with Improved Outcomes After Treatment Discontinuathion?" click here Poster "CD4 Activation Predicts Virologic Failure in HAART for Primary HIV" click here Poster "Interleukin-2 (IL-2) in Conjunction with HAART in Early HIV-1 Infection Increases Naïve and Memory CD4 Cells and Lowers Activation Markers" click here

The OPTIONS Project is a research study sponsored by UCSF. The goal of the OPTIONS Project is to learn as much as possible about early HIV infection and how transmission of HIV is occurring. OPTIONS is a study for people in the San Francisco area.ALL OPTIONS PROJECT SERVICES ARE FREE. Updated 02/25/2008 by OPTIONS Project team